Soon after the Spartans invade again, a deadly epidemic strikes the crowded city. Thucydides, who caught it himself, says no one remembered one so deadly.
Not many days after their arrival in Attica the plague first began to show itself among the Athenians.
The plague killed an estimated quarter of the city's people. In the long run it redistributed wealth within Athenian society and weakened Athens politically.
Based on Wikipedia: Plague of Athens
The plague killed an estimated 75,000 to 100,000 people, around 25% of the population
Long-term, the high death toll drastically redistributed wealth within Athenian society, and weakened Athens politically.